Pregaseed-M Tablet

“To cherish the most memorable moments of life”

Offers:

  • Ubidecarenone (Q10) 200mg
  • L-Carnitine 500mg
  • Astaxantin 8mg
  • Lycopene 5mg
  • Zinc ascorbate 5mg

Mrp: 365INR

Ubidecarenone:

Pharmacodynamics:

Ubidecarenon has roles in many prysiological process including sulfide oxidation, regulation of mitochondrial permeability transition pore and translocation of protons and calcium ions accross biological membranes. Ubidecarenone is an essential cofactor in the mitochondrial electron transport chain. Its functions are the acceptance of electrons from the complex I and II and this activity is vital for the production of ATP. Ubidecarenone also presents antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes as well as inhibiting oxidation of LDL-cholesterol.

Pharmacokinetics:

Ubidecarenone is absorbed from the small intestine into the lymphatics and then it can enter the blood. The hydrophobicity and large molecular weight limit its absorption making it very poor and variable depending on the food intake and the number of lipids presented in the food. The absorption is lower in the presence of an empty stomach and greater in presence of high lipid food diet. The main elimination route of ubidecarenone is through the bile. After its oral administration, over 60% of the dose is excreted in the feces in the form of unchanged ubidecarenone and a small fraction of the metabolites in the urine.

L-Carnitine:

Pharmacodynamics:

Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Lack of carnitine can lead to liver, heart, and muscle problems. Carnitine deficiency is defined biochemically as abnormally low plasma concentrations of free carnitine, less than 20 µmol/L at one week post term and may be associated with low tissue and/or urine concentrations. Levocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine

Pharmacokinetics:

After oral administration L-carnitine which is unabsorbed is metabolized in the gastrointestinal tract by bacterial microflora.
Absolute bioavailability is 15% (tablets or solution). Time to maximum plasma concentration was found to be 3.3 hours. Excretion takes place from the urine.\

Dosage:

One capsule BD for 3-6 months

Indication:

  • Improves sperm motility and sperm morphology
  • Increases sperm count
  • Promotes cardiovascular health
  • Secondary carnitine deficiency

 

Contraindication:

Hypersensitivity to Coenzyme Q10 / L- Carnitine is a contraindication and should not be used if allergic to the product.

Drug interaction:

Coenzyme Q10 / L- Carnitine may interact with the following drugs and products:

  • Antihypertensive drugs
  • Aspirin
  • Clopidogrel
  • Insulin
  • Warfarin

Side effects:

  • Nausea
  • Vomiting
  • Abdominal discomfort
  • Diarrhea
  • Anorexia
  • Allergic rash