Pregaseed-F

(Capsule)

“The next generation treatment options for PCOS and its complication”

Offers:

  • D-Chiro-Inositol 100mg
  • Chromium Picolinate 100mcg
  • Vitamin D3 1000IU
  • B-complex vitamins and multiminerals

Mrp: 350 INR

 

D-chiro-Inositol:

Pharmacodynamics:

D-Chiro-Inositol plays an important role in insulin signal transduction, and can help relieve symptoms of PCOS. D-Chiro-Inositol (DCI) is part of the inositol family. It is a secondary messenger in insulin signal transduction and it helps reduce insulin resistance. DCI has an essential role in the pathways of mitochondria that generate energy from sugar. DCI improves the metabolism of sugar and moderates the metabolism of glucose and sensitivity to insulin.

Pharmacokinetics:

Like myo-inositol, DCI is a member of the B vitamin family.  It is not a drug, but rather a nutritional supplement.  DCI plays a part of healthy metabolism and the body makes it from D-pinitol (another form of inositol) and myo-inositol. Myo-inositol is essentially a precursor to DCI. D-pinitol is found in many fruits and vegetables and myo-inositol in found in meats. D-pinitol’s only role in the body is to be converted to myo-inositol and then to DCI. The human body can, in principle, make DCI from either D-pinitol or myo-inositol, but in practice, some people do not make enough DCI.  The thought is that women with PCOS may not be able to convert efficiently to DCI. Low levels of DCI have been observed in women with impaired insulin sensitivity and PCOS. 

Dosage:

One capsule BD for 3-6 months

DCI is used during insulin signal transduction, the body’s response to insulin. If DCI is deficient, insulin resistance can develop. There is evidence that women with PCOS do not make enough DCI and many women with PCOS are insulin resistant. This deficiency leads to too much testosterone and the symptoms of PCOS. 

The primary function of DCI is not to provide energy. Its primary function is as part of an important small molecule used during insulin signal transduction, a chemical signal chain that tells our bodies how to dispose of sugar. These small molecules are often called, “secondary messengers”. Myo-inositol and DCI are indeed different molecules. They belong to two different signal cascades and regulate different biological processes. It is a biochemical twist of fate that a deficiency of DCI, itself a carbohydrate, can make it so hard to correctly metabolize sugars, our energy carbohydrates. DCI is not abundant in our diets. So our bodies have to make DCI. And if our PCOS bodies are not efficient at converting myo-inositol and D-pinitol, the chemical signal chain breaks down and leads to high blood sugar, high insulin levels, and high androgen levels. These conditions can lead to type II diabetes, PCOS, endometriosis, and other disorders. 

 

Advantage of DCI over Myo-Inositol:

  • DCI increases the action of insulin, and improves ovulatory function, decreases serum androgen, blood pressure and triglycerides
  • DCI decreases testosterone in women with PCOS 
  • DCI helps obese women with PCOS increase insulin sensitivity in particular, women who have diabetic relatives

Indication:

  • 1st line approach in PCOS overweight patients risk of metabolism disease
  • Restores menstruation
  • Increases insulin sensitivity
  • Decreases Oligomenorrhea and Amenorrhea

Contraindication:

Hypersensitivity to D-ChiroInositol is a contraindication.

Drug Interaction:

D-Chiro Inositol / Vitamin D3 may interact with the following drugs and products:

  • Actinomycin
  • Barbiturates
  • Cholestyramine
  • Glucocorticoids
  • Paraffin oil
  • Phenytoin

 

Side effects:

It can cause nausea, stomach pain, tiredness, headache, and dizziness. There is some concern that taking too much inositol might make bipolar disorder worse.