“Building strong bones need more than just calcium”

Offers:

• Calcium citrate malate 1000mg
• Vitamin D3 100 IU
• Folic acid 50mg

Mrp: 495 INR

Calcium citrate malate:

Calcium citrate malate with vitamin D3 is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Pharmacodynamics:

Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol.

Pharmacokinetics:

The percentage of calcium absorbed varies inversely with intake. About 46.4% of calcium is bound to plasma proteins. It is cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions. Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis. Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence.

Dosage:

One tablet once a day

Indication:

• Advanced osteoporosis

• Post menopausal osteoporosis

• Rickets

• Hypoparathyroidism

Contraindication:

• People who are at risk for high calcium levels
• Kidney disease
• Sarcoidosis
• Cancer
• Hyperparathyroidism

Drug Interaction:

• Calcium citrate malate and estrogen or diuretics may increase the levels of calcium in your body, leading to hypercalcemia.
• Taking calcium supplements and anti-seizure medications may reduce the amount of calcium in your body.
• Calcium citrate malate should not be taken in conjunction with antacids that contain aluminum as this combination of supplements may cause aluminum toxicity.

Side effects:

• Constipation
• Stomach Upset
• Nausea/Vomiting
• Loss of appetite
• Muscle pain
• Increased thirst
• Tiredness